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    Galantamine   Hydrobromide

  • Introduction
  • Specification

 

Galantamine hydrobromide is a plant alkaloid obtained from Lycoris Radiata, also named as nivaline.

It can inhibit the activity of acetylcholinesterase, but activate less in butylcholinesterase. Galantamine hydrobromide is one kind of tertiary amine, which can enter into brain cells and central nerve system. It is indicated for Alzheimer’s disease and senile dementia of Alzheimer’s type abroad.


Test

Acceptance criteria

Appearance

White or almost white, crystalline powder

Solubility

Soluble in water, very slightly soluble in ethanol, insoluble in acetone, chloroform and ethyl ether.

Specific optical rotation

-90° ~ -100°

Specific absorbance

79.6~86.2

Identification

Identified

Clarity of solution

Clear

pH

4.5~6.5

Related substances

Complies with CP2010

Loss on drying

Not more than 1.0%

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